Pregnancy risk assessment calculator

Pregnancy risk assessment calculator

Screening for early-onset preeclampsia

Blood sample

PAPP-A
Note: PlGF and PAPP-A raw values can be used only when measured by Roche analyzers. PlGF and PAPP-A MoM values can be used when measured by Roche or any other analyzers.
PlGF
Note: PlGF and PAPP-A raw values can be used only when measured by Roche analyzers. PlGF and PAPP-A MoM values can be used when measured by Roche or any other analyzers.

Maternal examination

Mean Arterial Blood Pressure
Uterine Arteries Doppler

Maternal characteristics

Check all that apply:
Yes / No

Result

  • Early-onset preeclampsia risk

The most appropriate cutoffs for preeclampsia screening depend on the basal risk of a specific population, the markers available for risk assessment and the desired detection rate for an acceptable false positive rate. The cutoffs provided by this calculator were obtained from a single cohort and might not be suitable for other populations.2 The suggested cutoffs should only be used as reference.
References

1. Serra B, Mendoza M, Scazzocchio E, Meler E, Nolla M, Sabrià E, Rodríguez I, Carreras E. A new model for screening for early-onset preeclampsia. Am J Obstet Gynecol. 2020 Jun;222(6):608.e1-608.e18. doi: 10.1016/j.ajog.2020.01.020. Epub 2020 Jan 21. PMID: 31972161.

2. Mendoza M, Tur H, Garcia-Manau P, Hurtado I, Serrano B, Lopez-Martinez RM, Castellote L, Martinez L, Bonacina E, Carreras E. Cut-off values for Gaussian first-trimester screening for early-onset preeclampsia with maternal history, biochemical markers and uterine artery Doppler. J Gynecol Obstet Hum Reprod. 2020. doi: 10.1016/j.jogoh.2020.101827.

3. Bartsch Emily, Medcalf Karyn E, Park Alison L, Ray Joel G. Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies BMJ 2016; 353 :i1753

4. Cuckle HS. Screening for pre-eclampsia--lessons from aneuploidy screening. Placenta. 2011 Feb;32 Suppl:S42-8. doi: 10.1016/j.placenta.2010.07.015. PMID: 21257082.

Individual risk assessment for prenatal counseling in early-onset growth-restricted and small-for-gestational-age fetuses

Risk by the sFlt-1/PlGF alone

Risk by a multivariable model without sFlt/PlGF

Umbilical artery PI
Uterine artery PI
NICE high risk criteria2 (check all that apply)
High risk
Moderate risk

Adverse outcomes

  • Delivery <30 w
    Risk of delivery before 30 weeks of gestation.
  • Delivery <34 w
    Risk of delivery before 34 weeks of gestation.
  • Delivery <37 w
    Risk of delivery before 37 weeks of gestation.
  • Adverse perinatal outcomes

    Risk of fetal or neonatal death, intrapartum cesarean delivery for non-reassuring CTG, respiratory distress syndrome, bronchopulmonary dysplasia, neonatal sepsis, retinopathy, periventricular leukomalacia, 5-min Apgar score under 5, UA cord pH under 7.

  • The risks obtained should not be used for making clinical decisions as they are based in a single study and have not underwent external validation.
References

1. Mendoza M, Hurtado I, Bonacina E, Garcia-Manau P, Serrano B, Tur H, Rodo C, Maiz N, Carreras E. Individual risk assessment for prenatal counseling in early-onset growth-restricted and small-for-gestational-age fetuses. Acta Obstet Gynecol Scand. 2020. doi: 10.1111/aogs.14032.

2. Hypertension in pregnancy: diagnosis and management NICE guideline Published: 25 June 2019 www.nice.org.uk/guidance/ng133

None of the parties involved in the development of this software will be responsible of the consequences of possible errors and / or malfunctions of it; nor of the consequences derived from its use. Every result must be verified by a trained healthcare professional.

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